GONADECTOMY ATTENUATES TURNING BEHAVHOR F I~:~ODUCED BY ELECTPdCAL ST~[MULATION OF THE NIGROST~IHATAL DOFAMINE SYSTEM iN FEMALE BUT NOT MALE RATS
نویسنده
چکیده
Rotational behavior induced by electrical stimulation of ascending dopamine neurons is used as a behavioral model to investigate gender and hormonal influences on extra-h)pothalamic doparmne systems. Steroid hormones influence the metabolism of many dopaminergic drugs, and therefore ihis approach avoids the complications inherent in drug-induced behavior models of dopamine activity. We found that gonadectomy of female, hut not male0 rats severely attenuates electrical stimulation-induced rotational behavior. This suggests that some female gonadal steroid hormone(s) may modulate the activiq c." ascending dopamine neurons, while male gonadal hormones do not.
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